장단기 고용량 카페인 투여가 청소년기 동물모델의 행동에 미치는 영향

• 영문명: Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence
• 발행기관: 한국기초간호학회
• 저자명: 박종민(Park Jong-Min) 김윤주(Kim Yoonju) 김하은(Kim Haeun) 김연정(Kim Youn-Jung)
• 간행물 정보: 『Journal of Korean Biological Nursing Science』제21권 제3호, 217~223쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2019.08.31

영문 초록

Purpose: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. Methods: The animals were divided into three groups: a “vehicle” group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a “Day 1” group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a “Day 14” group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats’activity levels, anxiety, and cognitive function. Results: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. Conclusion: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety- like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.

목차

Introduction

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키워드

Caffeine Adolescent Locomotion Anxiety Memory 카페인 청소년 활동 불안 기억