흰쥐의 알코올 유발성 간손상에 실비음(實脾飮)이 미치는 보호 효과

• 영문명: The Protective Effects of Silbi-um Extract on the Alcoholic Liver Injury in Rats
• 발행기관: 한방비만학회
• 저자명: 김범회(Bum Hoi Kim)
• 간행물 정보: 『대한한방비만학회지』제18권 2호, 74~82쪽, 전체 9쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2018.12.31

영문 초록

Objectives: The objective of this study is to investigate the effects of Silbi-um (SBU) extract on the alcoholic fatty liver induced by EtOH administration for 8 weeks. Methods: Male Sprague Dawley rats were used. All animals were randomly divided into 3 groups; Normal, EtOH and EtOH+SBU. The rats of EtOH group were daily treated with ethanol of 25% (v/v) for 8 weeks (n=10). EtOH+SBU group was orally treated with SBU water extract after ethanol administration (n=10). The rats of Normal group were treated with saline (n=10). After 8 weeks, the mean body weight, liver weight, and liver-body weight ratio were calculated. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of all groups were measured. The morphological alterations were observed using hematoxylin and eosin (H&E) and Oil Red O staining. Moreover, the alteration of tumor necrosis factor-α (TNF-α) levels were analyzed immunohistochemistrically. Results: The histological data showed that liver sections from EtOH group displayed severe steatosis. SBU extract significantly inhibited the progression of the alcoholic liver injury. The increased serum level of ALT and AST induced by ethanol administration were decreased by SBU extract. Furthermore, SBU extract significantly decreased the liver concentrations of TNF-α. Conclusions: SBU water extract attenuated the alcohol induced fatty liver by improving hepatic lipid metabolism via suppression of TNF-α protein. SBU could be effective in protecting the liver from alcoholic fatty liver.

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키워드

Alcoholic fatty liver Silbi-um Aspartate aminotransferase (AST) Alanine aminotransferase (ALT) Tumor necrosis factor-α(TNF-α)