학술논문
Anti-inflammatory effects of low-level laser in burn wound models in rats
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- 영문명
- Anti-inflammatory effects of low-level laser in burn wound models in rats
- 발행기관
- 물리치료재활과학회
- 저자명
- Eun-Jeong Kim Se-Hun Kim
- 간행물 정보
- 『Physical Therapy Rehabilitation Science』제6권 제4호, 170~175쪽, 전체 6쪽
- 주제분류
- 의약학 > 재활의학
- 파일형태
- 발행일자
- 2017.12.31
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국문 초록
영문 초록
Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated.
Design: Randomized controlled trial.
Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser (1.2 J/cm2) treatment after a burn wound; Group III received dressing film and low-level laser (2.3 J/cm2) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was observed every day and the burn area diameter and retraction quantification at 1, 7, and 14 days were evaluated. Low-level laser was investigated on hematological parameters after 14 days. Effects of low-level laser on the inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]) concentrations in the serum were evaluated using immunosorbent assay kits.
Results: Group III showed a significant difference in wound size on days 7 and 14 compared to Group I (p<0.05). Group II showed a significant difference in wound size on day 14 compared to Group I (p<0.05). For wound contraction percentage, both laser therapy treatment groups showed a significant difference compared with Group I (p<0.05). There was also a significant difference in wound contraction percentage in Group III compared to Group II (p<0.05). Compared with the model control group, decreased TNF-α and IL-6 levels in the serum was observed at 14 days after burn wound induction.
Conclusions: The results of this study suggest that low-level laser therapy can assist in burn wound healing, which might be associated with decreased concentrations of TNF-α and IL-6 related proinflammatory cytokines.
목차
Introduction
Methods
Results
Discussion
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