학술논문
Effects of cardiac biological activities on low-intensity physical training in doxorubicin-induced cardiotoxicity rat models
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- 영문명
- Effects of cardiac biological activities on low-intensity physical training in doxorubicin-induced cardiotoxicity rat models
- 발행기관
- 물리치료재활과학회
- 저자명
- Yeong-Kye Ki Gye-Yeop Kim Eun-Jung Kim
- 간행물 정보
- 『Physical Therapy Rehabilitation Science』제3권 제2호, 107~111쪽, 전체 5쪽
- 주제분류
- 의약학 > 재활의학
- 파일형태
- 발행일자
- 2014.12.31
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국문 초록
영문 초록
Objective: In the present study, we investigated the protective effects of low-intensity treadmill training in doxorubicin-induced cardiotoxicity rat models.
Design: Randomized controlled trial.
Methods: In this study, we randomly divided them into four groups. The normal group included non-cardiotoxicity normal control (n=10), the control group included non-treadmill training after doxorubicin-induced cardiotoxicity (n=10), the experimental group I included low-intensity treadmill training (3 m/min) after doxorubicin-induced cardiotoxicity (n=10), and the experimental group II included low-intensity treadmill training (8 m/min) after doxorubicin-induced cardiotoxicity (n=10). Rats in the treadmill training group underwent treadmill training, which began at 2 weeks after first intraperitoneal injection. We determined the body weight change for each rat on days 1 and 21. Biochemical markers (lactate dehydrogenase [LDH], creatine kinase [CK], glutathion, aspartate transaminase [AST], and alanine transaminase [ALT]) concentration in the serum change of rats from all four groups was examined at the end of the experiment.
Results: The results showed that the experimental group I and II showed a significant increase in body weight as compared with that of the control group (p<0.05). We observed that the biochemical markers (LDH, CK, glutathion, AST, and ALT) were improved in the experimental group I than the experimental group II (p<0.05). There was no difference between the experimental groups.
Conclusions: In conclusion, our data suggest that low-intensity treadmill training applied after doxorubicin treatment protects against cardiotoxicity following treatment, possibly by enhancing antioxidant defenses and inhibiting cardiac muscle cell apoptosis.
목차
Introduction
Methods
Results
Discussion
Conflict of Interest
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