Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate

• 발행기관: 한국탄소학회
• 저자명: Shou-Cang Shen Wai Kiong Ng Kumaran Letchmanan Ron Tau Yee Lim Reginald Beng Hee Tan
• 간행물 정보: 『Carbon Letters』 제27권, 18~25쪽, 전체 8쪽
• 주제분류: 자연과학 > 자연과학일반
• 파일형태: PDF
• 발행일자: 2018.07.31

영문 초록

In this study, graphene oxide(GO) was used as drug carriers to amorphize poorly watersoluble drugs via a co-spray drying process. Two poorly water-soluble drugs, fenofibrate and ibuprofen, were investigated. It was found that the drug molecules could be in the graphene nanosheets in amorphous or nano crystalline forms and thus have a significantly enhanced dissolution rate compared with the counterpart crystalline form. In addition, the dissolution of the amorphous drug enwrapped with the graphene oxide was higher than that of the amorphous drug in activated carbon (AC) even though the AC possessed a larger specific surface area than that of the graphene oxide. The amorphous formulations also remained stable under accelerated storage conditions (40°C and 75% relative humidity) for a study period of 14 months. Therefore, graphene oxide could be a potential drug carrier and amorphization agent for poorly water-soluble drugs to enhance their bioavailability.

목차

1. Introduction

2. Experimental

3. Results and Discussion

4. Conclusions

Conflict of Interest

Acknowledgements

References

키워드

graphene oxide capsulation dissolution rate crystallinity physical stability