Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats

• 영문명: Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Gustavo Guevara-Balcazar Israel Ramirez-Sanchez Elvia Mera-Jimenez Ivan Rubio-Gayosso Maria Eugenia
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제21권 제4호, 407~413쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2017.01.01

영문 초록

Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial pressure and inflammatory processes). The aim of this study was to analyze changes in the contractile response to phenylephrine of thoracic/abdominal aorta and the coronary artery during aging in rats. Three groups of rats were formed and sacrificed at three distinct ages: prepubescent, young and old adult. The results suggest that there is a higher participation of prostanoids in the contractile effect of phenylephrine in pre-pubescent rats, and a lower participation of the same in old rats. Contrarily, there seems to be a higher participation of prostanoids in the contractile response of the coronary artery of older than pre-pubescent rats. Considering that the changes in the expression of COX-2 were similar for the three age groups and the two tissues tested, and that expression of COX-1 is apparently greater in older rats, COX-1 and COX-2 may lose functionality in relation to their corresponding receptors during aging in rats.

키워드

Aorta Cyclooxygenase Development Heart Phenylephrine