Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response

• 영문명: Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Kyeong Eun Hyung Soo Jeong Kim Ye Won Jang Da Kyoung Lee Kee Hyeob Hyun Byoung Seok Moon Bongjoon Ki
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제21권 제3호, 335~343쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2017.01.01

영문 초록

Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-γ, and IL-6,which were stimulated by house dust miteextracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC⁄Nga mice after onset of the disease by altering immune cell activation. The Lactobacillus strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD.

키워드

Atopic Dermatitis Dermatophagoides farinae Lactobacillus Probiotics Th2 cells