Induction of Oscillatory Firing Activity by TTX in Rat Cerebellar Purkinje Cells

• 영문명: Induction of Oscillatory Firing Activity by TTX in Rat Cerebellar Purkinje Cells
• 발행기관: 대한생리학회
• 저자명: Seo, Wha-Sook
• 간행물 정보: 『대한생리학회지』제29권 제1호, 103~111쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

Intracellular recordings were obtained from Purkinje cells in rat cerebellar slices maintained in vitro. Adding tetrodotoxin to the superfusion solution produced a typical pattern of repetitive burst firing consisting of a cluster of action potentials followed by a long hyperpolarization. TTX-induced oscillatory activity was not due to modulation of membrane potential although underlying mechanisms for maintenance of oscillatory activity were influenced by membrane voltage. The mechanism of TTX-induced oscillation was not related to the presence or amplitude of I_h] and could still induce the oscillatory activity after blockade of I_h] by cesium. The result from an experiment in which QX-314 was injected intracellularly strongly suggested that TTX-induced oscillatory firing activity was due to blockade of post-synaptic Na⁺ currents intrinsic to PCs.

키워드

Purkinje cell Oscillatory firing activity Sodium current Tetrodotoxin