칼슘이 결장뉴 K-경축에 미치는 영향

• 영문명: Effect of Calcium Ion on K-contracture in Guinea Pig s Taenia Coli
• 발행기관: 대한생리학회
• 저자명: 조성일(Cho, Sung-Il) 엄대용(Uhm, Dae-Yong) 이상돈(Rhee, Sang-Don)
• 간행물 정보: 『대한생리학회지』제16권 제1호, 25~30쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1982.06.30

영문 초록

The in vitro experiments for isometric contraction were done to investigate the different action mechanism of calcium ion on phasic and tonic components of K-contracture in guinea pig s taenia coli. The results were as follows: 1) The degrees of K-contracture were increased gradually from 4 mM to 15, 20, 40 & 100 mM of[K⁺]₀. The maximal developed tension in tonic component was observed in 100 mM of [K⁺]₀. 2) The phasic components were not so affected by 2, 4, 8 & 16 mM of [Ca⁺⁺]₀ in 100 mM K-contracture, but the tonic components were gradually increased in a dose-responsive manner. 3) The K-contracture was not influenced by norepinephrine, 1 mg/l, but was completely abolished by verapamil, 2 mg/l. 4) The phasic component was little affected by verapamil, 0.01 mg/l, 0.1 mg/l, and 1 mg/l, but the tonic component was completely disappeared at the concentration of verapamil 1 mg/l. The above results suggest that [Ca⁺⁺]₀. primarily affected the tonic component than the phasic component of K-contracture in guinea pig s taenia coli.