시상하부내로 투여한 Tetrodotoxin이 혈압 및 시상하부의 전기자극에 의한 승압반응에 미치는 영향

• 영문명: Effect of Intrahypothalamically Injected Tetrodotoxin on Pressor Responses to Electrical Stimulation in tao Hypothalamus
• 발행기관: 대한생리학회
• 저자명: 김종식(Kim, Jong-Shik) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제11권 제2호, 23~32쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1977.12.31

영문 초록

It is Proposed in the Present study to investigate the effects of TTX intravenously or intrahypothalamically administered on the arterial blood pressure and respiration and also to explorc effect of intrahypothalamically administered TTX on the pressor responses to electrical stimulation in the hypothalamus. The results obtained are as follows; 1) The pressor responses to electrical stimulation in the hypothalamus were markedly reduced after administration of TTX. In the 0.01 μg/kg of TTX administered group, the pressor responses were almost abolished in 6 minutes and there was no tendency toward recovery throughout the experiment. 2) In 0.01 μg/kg of TTX administered group, the mean arterial blood pressure and heart rate-were gradually reduced while there was a transient increase in respiratory rate followed by slow recovery thereafter. On the other hand no changes in arterial blood pressure, heart rate an4 respiration were observed in 0.005 μg/kg TTX administered group. 3) Following intravenous administration of 1 μg/kg TTX, the arterial blood pressure and heart rate were slowly reduced by 60 minutes while no marked changes were found in respiration. From the results of present study it is strongly suggested that TTX exerts its depressant effect not only on peripheral nerves but also on central nervous system.