미성숙 돼지 자궁 평활근의 운동성에 대한 Adenosine Triphosphate와 Prostaglandin F2α 작용의 관계

• 영문명: Relationship of Action of Adenosine Triphosphate and Prostaglandin F_2α on Uterine Smooth Muscle Motility in Immature Pig
• 발행기관: 대한생리학회
• 저자명: 김주헌(Kim, Joo-Heon) 권종국(Kwun, Jong-Kuk) 김용근(Kim, Yong-Keun)
• 간행물 정보: 『대한생리학회지』제22권 제1호, 31~40쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1988.06.30

영문 초록

This study was carried out to investigate the action of adenosine triphosphate (ATP) on the motility of immature pig uterine smooth muscle. ATP appeared contractile responses in a dose-dependent manner, showing the maximal contraction at the concentration of 10^-3M in the uterine smooth muscle strip. The contractile responses by ATP(10^-4M) were not affected by atropine (10^-6M), phentolamine (10^-6M), propranolol (10^-6M), pyrilamine (10^-6M), cimetidine (10^-6M), and theophyulline (5 X 10^-5M), but were inhibited uncompetitively by quinidine. The effects of these drugs on the contractile responses by prostaglandin F_2α(PGF_2α) were also comparable to those observed with ATP. When muscle strips were pretreated with indomethacin (5 X 10^-5M) for 20 min., the contractile responses by ATP(10^-4M) were completely inhibited. But the contractile responses by PGF_2α were not affected by indomethacin. These results suggest that ATP elicited the contraction through noncholinergic- and nonadrenergic-receptor mediated by prostaglandin F_2α in pig uterine smooth muscle.

키워드

Noncholinergic- and nonadrenergic-receptor ATP Prostaglandin F_2α Uterine smooth muscle contraction