Spontaneously Hypertensive Rat에 있어서 Atrial Natriuretic Peptide의 신장기능과 몇가지 호르몬 분비에 미치는 영향

• 영문명: Effects of Atrial Natriuretic Peptide on Renal and Endocrine Functions in Spontaneously Hypertensive Rats
• 발행기관: 대한생리학회
• 저자명: 김산호(Kim, San-Ho) 김선희(Kim, Suhn-Hee) 설경환(Seul, Kyung-Hwan) 조경우(Cho, Kyung-Woo)
• 간행물 정보: 『대한생리학회지』제22권 제1호, 41~54쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1988.06.30

영문 초록

The present study was undertaken to clarify the involvement of atrial natriuretic peptide in the development of hypertension in spontaneously hypertensive rats. Plasma concentration of immunoreactive atrial natriuretic peptide was higher in spontaneously hypertensive rats than in normotensive Sprague-Dawley and Wistar rats. Plasma renin concentration was lower in SHR than in normotensive rats, as observed in earlier experiments. Hydration-induced increase in urine flow and urinary excretions of sodium and potassium were smaller in SHR than in normotensive control rats. Intraarterial infusion of atrial natriuretic peptide resulted in increases in urine flow, urinary excretions of sodium and potassium in both hypertensive and normotensive rats. Renal response to atrial natriuretic peptide was markedly suppressed in SHR. Plasma renin and aldosterone concentration were suppressed by atrial natriuretic peptide in both SHR and normotensive rats. The responses were not significantly different in both groups. These results suggest that the renal responsiveness to atrial natriuretic peptide may be suppressed in SHR by some mechanisms still remaining obscure.

키워드

SHR Atrial natriuretic peptide Renin Aldosterone Kidney