교감신경성 수용체 차단이 Digitalis독성에 미치는 영향

• 영문명: Effects of Adrenergic Receptor Blockade on Digitalis Intoxication in Mice
• 발행기관: 대한생리학회
• 저자명: 강희룡(Kang, Hee-Ryong)
• 간행물 정보: 『대한생리학회지』제7권 제2호, 67~71쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1973.12.31

영문 초록

This experiment was carried out to investigate the influence of adrenergic receptor blockade. on digitalis intoxication. The effects of adrenergic alpha and beta receptor blockade on the lethal dose of digitonin were evaluated. LD₅₀ and dose mortality curve of digitonin in mice pretreated with dibenzylin or propranolol hydrochloride (Inderal) were obtained. All drugs were injected subcutaneously. Digitonin toxicity was significantly decreased in mice pretreated with beta¡¤blockade compare with alpha-blockade and control groups.