Rehmanniae Radix에 의한 가토 동방결절 및 유두근의 활동전압의 변동

• 영문명: Effects of Ethanol Extract of Rehmanniae Radix(RREE) on Resting and Action Potential of Rabbit Sinoatrial Node and Papillary Muscle
• 발행기관: 대한생리학회
• 저자명: 황보상(Hwang, Bo-Sang) 고상돈(Koh, Sang-Don) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제19권 제2호, 127~138쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1985.12.31

영문 초록

The present study was undertaken in order to investigate effect of ethanol extract of Rehmanniae radix(RREE) on electrophysiology of sinus node and papillary muscle. Rehmanniae radix is a herbal medicine which has been known to have diuretic, antipyretic, hemopoietic and cardiotonic effects. Action potentials were recorded by means of glass capillary microelectrode(technique) in rabbit sinoatrial nodal cells and papillary muscle cells which were superperfused with either tyrode solution or tyrode solutions containing different amount of RREE. The results obtained were as follows ; 1) In both central and peripheral nodal cells maximum diastolic potential (MDP) and amplitude of action potential (APA) were not affected by RREE. 2) Action potential duration as expressed APD₆₀(time to 60% repolarization) of central and peripheral pacemaker cells were significantly prolonged following perfusion with tyrode solution containing 0.1% RREE. 3) The rates of spontaneous firing from central pecemaker cell were decreased by RREE at concentration of 0.05% and 0. 1% while spontaneous rhythm of perinodal cell was decreased by 0.1% RREE. 4) The action potential duration of papillary muscle as expressed APD₆₀ were prolonged by 0.1% RREE.