Kanendomycin이 토끼 적혈구막의 포타슘 투과에 미치는 영향

• 영문명: The Effects of Kanendomycin on the Potassium Permeability of the Rabbit Erythrocyte Membrane
• 발행기관: 대한생리학회
• 저자명: 김정한(Kim, Jung-Han)
• 간행물 정보: 『대한생리학회지』제8권 제1호, 45~54쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1974.06.30

영문 초록

The effects of kanendomycin on the potassium permeability in the rabbit erythrocyte membrane are investigated and the results are summarized as follows. 1. Kanendomycin causes the efflux of K⁺ and influx of Na⁺ across the rabbit erythrocyte membrane. 2. Osmotic resistance of kanendomycin treated erythrocytes is diminished. This diminution of osmotic resistance is more pronounced by increasing concentration of kanendomycin and longer incubation time. But osmotic resistance is rather increased in the presence of lower concentration of kanendomycin. 3. Cysteine and glutathione have little influence on K⁺ efflux induced by kanendomycin. 4. EDTA has no effect on the increase in K⁺ outflux by kanendomycin while PCMB augments slightly on K⁺ outflux. 5. Kanendomycin inhibits Ca⁺⁺ binding competitively to rabbit erythrocyte membrane fragments.