Completion of Chronic Hepatitis C Virus Treatment in Interferon-Induced Major Depressive Disorder with Psychotic Features

• 발행기관: 대한신경정신의학회
• 저자명: Susie H. Park
• 간행물 정보: 『Psychiatry Investigation』제8권 제4호, 381~383쪽, 전체 3쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2011.12.31

영문 초록

Interferon (IFN)-associated psychiatric disorders can be managed without interruption to hepatitis C virus (HCV) treatment. The limited number of cases in the literature reporting psychotic depression as an adverse drug reaction to IFN resulted in discontinuation of HCV therapy. The author reports a case of a 49 year-old man with chronic HCV genotype 1a treated with pegylated interferon-alpha and ribavirin developing major depressive disorder with psychotic features. The patient was successfully treated with both an antidepressant and antipsychotic for this suspected IFN-associated adverse drug effect while continuing 12 months of uninterrupted HCV treatment and subsequently achieving sustained hepatitis C virological response. Although IFN can cause distressing psychiatric disturbances, appropriate treatment with psychotropic agents and careful monitoring allows patients to be maintained on a full course of HCV treatment.

목차

INTRODUCTION

CASE

DISCUSSION

REFERENCES

키워드

Chronic hepatitis C virus Pegylated interferon-alpha Psychotic depression Major depressive disorder Psychosis Antipsychotic