정신분열병의 임상적 고위험군의 특징： ‘서울청년클리닉’의 자연 추적 관찰 예비연구

• 영문명: Characteristics of Subjects at Clinical High Risk for Schizophrenia： Natural Follow up Study in ‘Seoul Youth Clinic’- Pilot Study
• 발행기관: 대한신경정신의학회
• 저자명: 유소영 이경진 강도형 이승재 하태현 위휘 이애라 송지연 김성년 권준수
• 간행물 정보: 『신경정신의학』제46권 제1호, 19~28쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2007.01.30

영문 초록

Objectives：The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods：Symptomatic individuals judged at high risk for schizophrenia (‘clinical high risk’) within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results：Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the clinical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion：This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

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키워드

Schizophrenia Clinical high risk Neurocognitive function Social function Affective function