C2C12 골격근 세포에서 육계, 부자, 갈근 물 추출물의 당대사 및에너지 조절 효과

• 영문명: Original Article : The Effects of Cinnamomum cassia Blume, Aconitum carmichaeli Debx, and Pueraria lobata Benth on Glucose and Energy Metabolism in C2C12 Myotubes
• 발행기관: 한방비만학회
• 저자명: 송미영(Mi Young Song)
• 간행물 정보: 『대한한방비만학회지』제15권 2호, 131~136쪽, 전체 6쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2015.12.31

영문 초록

Objectives: The prevalence of obesity and metabolic syndrome is increasing worldwide. Regulation of cellular energy metabolis has the potential to be manipulated therapeutically to serve as a target for obesity and insulin resistance. Skeletal muscle is regarded as a target for regulation of energy metabolism and insulin resistance. In this study, the authors investigated the regulatory effect of (Cinnamomum cassia Blume, CCB), Aconitum carmichaeli Debx (ACD), and Benth (Pueraria lobata Benth, PLB) on energy and glucose metabolism in C2C12 myotubes. Methods: The water extracts of CCB, ACD, and PLB (0.5 mg/ml) were treated in differentiated C2C12 myotubes. The expressions of adenosine monophosphate-activated protein kinase (AMPK) and phosphorylation AMPK were detected with western blotting. Glucose metabolism was investigated with glucose uptake assay and glucose consumption assay, total adenosine triphosphate (ATP) content was also analyzed. Results: CCB, ACD, and PLB activated the phophorylation of AMPK, they also increased the glucose metabolism and total ATP contents in C2C12 myotubes. Conclusions: This study suggests that CCB, ACD, and PLB have the potential to increase energy and glucose metabolism in skeletal muscle.

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키워드

Cinnamomum cassia Blume Aconitum carmichaeli Debx Pueraria lobata Benth Glucose Energy C2C12