Synthesis, characterization, and toxicity of multi-walled carbon nanotubes functionalized with 4-hydroxyquinazoline

• 영문명: Synthesis, characterization, and toxicity of multi-walled carbon nanotubes functionalized with 4-hydroxyquinazoline
• 발행기관: 한국탄소학회
• 저자명: Hasan Tahermansouri Atieh Mirosanloo Saeed Heidari Keshel Mossa Gardaneh
• 간행물 정보: 『Carbon Letters』제17권 제1호, 45~52쪽, 전체 8쪽
• 주제분류: 자연과학 > 자연과학일반
• 파일형태: PDF
• 발행일자: 2016.01.31

영문 초록

The attachment of 2-aminobenzamide to carboxylated multi-wall carbon nanotubes (MWCNTs)- COOH was achieved through the formation of amide bonds. Then, the functionalized MWCNTs, MWCNT-amide, were treated by phosphoryl chloride to produce MWCNT-quin. The products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, thermogravimetric analysis, derivative thermogravimetric, steady-state fluorescence spectroscopy, and solubility testing. MWCNT-quin showed photo-electronic properties, which is due to the attachment of the 4-hydroxyquinazoline groups to them as proved by steady-state fluorescence spectroscopy. This suggests intramolecular interactions between the tubes and the attached 4-hydroxyquinazoline. The toxicity of the samples was evaluated in human embryonic kidney HEK293 and human breast cancer SKBR3 cell lines, and the viable cell numbers were measured by 3-(4,5-dimethyl- 2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) after the cells were cultured for 24 h. Cellular investigations showed that the modified MWCNTs, particularly MWCNT- quin, have considerably significant toxic impact on SKBR3 as compared to HEK293 at the concentration of 5 μg/mL.

목차

1. Introduction

2. Experimental

3. Results and Discussion

4. Conclusions

References

키워드

carbon nanotube functionalization MTT 4-hydroxyquinazoline toxicity