본문 바로가기

추천 검색어

실시간 인기 검색어

학술논문

Bangpungtongsung-san reduces the expression of angiotensin-converting enzyme 2 by blocking activating protein-1 activity in stimulated human mast cells

이용수 0

영문명
발행기관
셀메드 세포교정의약학회
저자명
Yu-Jin Choi Kyung-Min Jeong Hyun-Ja Jeong
간행물 정보
『셀메드』Volume 15 Issue 2, 1~8쪽, 전체 8쪽
주제분류
의약학 > 의학일반
파일형태
PDF
발행일자
2025.02.28
무료

구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.

1:1 문의
논문 표지

국문 초록

Bangpungtongsung-san (BTS) is a traditional prescription that has been used for inflammation and bronchial diseases. Coronavirus disease in 2019 (COVID-19), which occurs due to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a respiratory inflammatory disease, and mast cells are one of the key cells involved in the cytokine storm. In this study, we aimed to investigate the regulatory effects and mechanisms of BTS and its active compound, α-pinene, on coronavirus infections and inflammatory responses. BTS and α-pinene decreased the expression of not only angiotensin-converting enzyme 2 (ACE2) but also transmembrane protease/serine subfamily member 2 (TMPRSS2) in stimulated human mast cell line, HMC-1 cells. Additionally, BTS and α-pinene significantly suppressed the release of key inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, thymic stromal lymphopoietin, and tumor necrosis factor-α, without compromising cell viability. Furthermore, BTS and α-pinene decreased the expression of transcription factors c-Fos and c-Jun in activated HMC-1 cells. In conclusion, the results of the study indicated that BTS inhibited the c-Jun/c-Fos signaling pathway, leading to a decrease in the levels of ACE2, TMPRSS2, and inflammatory cytokines. This suggests that BTS may be an effective agent in mitigating the cytokine storm induced by SARS-CoV-2 infection.

영문 초록

목차

INTRODUCTION
MATERIALS & METHODS
RESULTS
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES

키워드

해당간행물 수록 논문

참고문헌

교보eBook 첫 방문을 환영 합니다!

신규가입 혜택 지급이 완료 되었습니다.

바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!

교보e캐시 1,000원
TOP
인용하기
APA

Yu-Jin Choi,Kyung-Min Jeong,Hyun-Ja Jeong. (2025).Bangpungtongsung-san reduces the expression of angiotensin-converting enzyme 2 by blocking activating protein-1 activity in stimulated human mast cells. 셀메드, 15 (2), 1-8

MLA

Yu-Jin Choi,Kyung-Min Jeong,Hyun-Ja Jeong. "Bangpungtongsung-san reduces the expression of angiotensin-converting enzyme 2 by blocking activating protein-1 activity in stimulated human mast cells." 셀메드, 15.2(2025): 1-8

결제완료
e캐시 원 결제 계속 하시겠습니까?
교보 e캐시 간편 결제