Bangpungtongsung-san reduces the expression of angiotensin-converting enzyme 2 by blocking activating protein-1 activity in stimulated human mast cells

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Yu-Jin Choi Kyung-Min Jeong Hyun-Ja Jeong
• 간행물 정보: 『셀메드』Volume 15 Issue 2, 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.02.28

국문 초록

Bangpungtongsung-san (BTS) is a traditional prescription that has been used for inflammation and bronchial diseases. Coronavirus disease in 2019 (COVID-19), which occurs due to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a respiratory inflammatory disease, and mast cells are one of the key cells involved in the cytokine storm. In this study, we aimed to investigate the regulatory effects and mechanisms of BTS and its active compound, α-pinene, on coronavirus infections and inflammatory responses. BTS and α-pinene decreased the expression of not only angiotensin-converting enzyme 2 (ACE2) but also transmembrane protease/serine subfamily member 2 (TMPRSS2) in stimulated human mast cell line, HMC-1 cells. Additionally, BTS and α-pinene significantly suppressed the release of key inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, thymic stromal lymphopoietin, and tumor necrosis factor-α, without compromising cell viability. Furthermore, BTS and α-pinene decreased the expression of transcription factors c-Fos and c-Jun in activated HMC-1 cells. In conclusion, the results of the study indicated that BTS inhibited the c-Jun/c-Fos signaling pathway, leading to a decrease in the levels of ACE2, TMPRSS2, and inflammatory cytokines. This suggests that BTS may be an effective agent in mitigating the cytokine storm induced by SARS-CoV-2 infection.

목차

INTRODUCTION

MATERIALS & METHODS

RESULTS

DISCUSSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENT

REFERENCES

키워드

Bangpungtongsung-san SARS-CoV-2 ACE2 Mast cell