Successful treatment of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw: a report of two cases

• 발행기관: 대한구강악안면외과학회
• 저자명: Ra-yeon Kim Sung ok Hong Jae-woong Jung Mu-hang Lee Young-kee Lee Yu-jin Jee
• 간행물 정보: 『대한구강악안면외과학회지』제50권 제5호, 285~291쪽, 전체 7쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2024.10.31

국문 초록

Medication-related osteonecrosis of the jaw (MRONJ) is a refractory disease that can lead to severe destruction of the jaw. As there is no standard protocol for treating MRONJ, various treatments have been studied. Teriparatide has been used as an adjunct therapy for MRONJ. However, its effectiveness has not been sufficiently demonstrated for use as a standard treatment for MRONJ. This study aimed to demonstrate the efficacy of teriparatide in treating MRONJ by presenting two successfully treated cases. Each patient received teriparatide therapy with surgical intervention. The appropriateness of teriparatide use was evaluated based on the patient’s systemic condition, and the administration of teriparatide was supervised by a physician. Complete resolution of the lesion was observed clinically and radiographically in both patients. The first patient underwent implant placement at the lesion site. Due to its anabolic properties and ability to stimulate bone remodeling, teriparatide is an effective adjunctive pharmacological treatment for bone healing before and after surgery with associated beneficial effects on bone and mucosal healing.

목차

Ⅰ. Introduction

Ⅱ. Cases Report

Ⅲ. Discussion

ORCID

Authors’ Contributions

Funding

Ethics Approval and Consent to Participate

Conflict of Interest

References

키워드

Bisphosphonate-associated osteonecrosis of the jaw Teriparatide Parathyroid hormone Osteoporosis