학술논문
Exploring the role of angiogenesis in fibrosis and malignant transformation in oral submucous fibrosis: a systematic review and meta-analysis
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- 영문명
- 발행기관
- 대한구강악안면외과학회
- 저자명
- Keerthika R Akhilesh Chandra Dinesh Raja Mahesh Khairnar Rahul Agrawal
- 간행물 정보
- 『대한구강악안면외과학회지』제50권 제5호, 243~252쪽, 전체 10쪽
- 주제분류
- 의약학 > 일반외과학
- 파일형태
- 발행일자
- 2024.10.31
4,000원
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국문 초록
Angiogenesis is a crucial molecular driver of fibrosis in various inflammatory lesions. Oral submucous fibrosis (OSMF) is a chronic inflammatory fibrotic disorder with malignant potential. The angiogenetic pathways in OSMF remain obscure due to limited research, necessitating an in-depth review. This review aimed to illuminate the cryptic pathogenetic mechanisms of angiogenesis in the disease progression/fibrosis of OSMF and its malignant transformation, providing insights for improved treatment. Extensive literature searches were conducted across an array of databases until October 2023. Original research articles on angiogenesis in OSMF were included, and the risk of bias was assessed using the modified Newcastle-Ottawa scale. RevMan ver. 5.4 (Cochrane Collaboration) was used for data analysis. Thirty-four articles were included for qualitative synthesis and seven for quantitative analysis. Findings revealed that angiogenesis was significantly increased in early-stage OSMF but decreased as the disease advanced. It was also associated with the severity of epithelial dysplasia and malignant transformation. A random-effects model confirmed the upregulation of angiogenesis as a significant risk factor in early-stage fibrosis and malignant transformation. The mounting evidence reinforces that angiogenesis plays a crucial role in the progression of early-stage fibrosis of OSMF and its malignant transformation, opening avenues for diagnostic and therapeutic interventions.
영문 초록
목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Conclusion
ORCID
Authors’ Contributions
Funding
Supplementary Materials
Conflict of Interest
References
해당간행물 수록 논문
- Author’s reply to the letter to the editor of Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Peripheral ossifying fibroma arising from the maxillary bucco-palatal gingiva in an elderly male patient: a rare case report
- Analysis of postsurgical relapse patterns in one-jaw surgery: skeletal factors and clustering analysis in patients with mandibular setback
- Efficacy of dextrose prolotherapy on temporomandibular disorder: a retrospective study
- Feasibility of navigation-assisted endoscopic transnasal optic nerve decompression for the treatment of traumatic optic neuropathy in patients with midfacial fractures
- Comment on “An unusual presentation of peripheral ameloblastoma in the maxilla”
- Unraveling the mystery of implant-related sequestration: a biomechanical breakthrough with far-reaching implications
- Exploring the role of angiogenesis in fibrosis and malignant transformation in oral submucous fibrosis: a systematic review and meta-analysis
- Quantum of incisal compensation in skeletal class III malocclusion: a cross-sectional study
- Successful treatment of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw: a report of two cases
- Laryngospasm following orthognathic surgery: an unusual case report
참고문헌
관련논문
의약학 > 일반외과학분야 NEW
- Author’s reply to the letter to the editor of Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Peripheral ossifying fibroma arising from the maxillary bucco-palatal gingiva in an elderly male patient: a rare case report
- Analysis of postsurgical relapse patterns in one-jaw surgery: skeletal factors and clustering analysis in patients with mandibular setback
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