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A Review of Novel Medical Treatments for Thyroid Eye Disease

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영문명
A Review of Novel Medical Treatments for Thyroid Eye Disease
발행기관
대한안과학회
저자명
Jeong Woo Park Jin Sook Yoon
간행물 정보
『The Korean Journal of Ophthalmology』Vol.38 No.3, 249~259쪽, 전체 11쪽
주제분류
의약학 > 의학일반
파일형태
PDF
발행일자
2024.05.31
4,120

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국문 초록

Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves disease. There has been no effective medication to prevent proptosis in thyroid eye disease until 2020 when the anti-insulin-like growth factor 1 receptor (anti-IGF-1R) antibody, Teprotumumab, was approved by the US Food and Drug Administration, sparking increased interest in immune-based drug development. This study aims to review the newly developed drug therapy as well as conventional treatment for TED. Treatment of TED has traditionally been high-dose steroids and orbital radiotherapy, but recently there has been a paradigm shift in the treatment of TED in the United States with the introduction of the therapeutic agent teprotumumab, which dramatically reduces proptosis. However, concerns remain about the development of hearing impairment as a potentially fatal complication and long-term safety. Recently, several clinical trials are underway to assess the efficacy and safety of novel drugs targeting mammalian target of rapamycin complex 1, interleukin-6, fragment crystallizable receptor, and IGF-1R in treating TED. With the explosive increase in interest from academia and pharmaceutical companies in TED, there is anticipation for the development of drugs that are equivalent or superior to teprotumumab while being safer.

영문 초록

목차

Introduction
Conventional Treatments
Novel Treatments
Conclusion
References

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APA

Jeong Woo Park,Jin Sook Yoon. (2024).A Review of Novel Medical Treatments for Thyroid Eye Disease. The Korean Journal of Ophthalmology, 38 (3), 249-259

MLA

Jeong Woo Park,Jin Sook Yoon. "A Review of Novel Medical Treatments for Thyroid Eye Disease." The Korean Journal of Ophthalmology, 38.3(2024): 249-259

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