A Review of Novel Medical Treatments for Thyroid Eye Disease

• 영문명: A Review of Novel Medical Treatments for Thyroid Eye Disease
• 발행기관: 대한안과학회
• 저자명: Jeong Woo Park Jin Sook Yoon
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.38 No.3, 249~259쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.05.31

국문 초록

Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves disease. There has been no effective medication to prevent proptosis in thyroid eye disease until 2020 when the anti-insulin-like growth factor 1 receptor (anti-IGF-1R) antibody, Teprotumumab, was approved by the US Food and Drug Administration, sparking increased interest in immune-based drug development. This study aims to review the newly developed drug therapy as well as conventional treatment for TED. Treatment of TED has traditionally been high-dose steroids and orbital radiotherapy, but recently there has been a paradigm shift in the treatment of TED in the United States with the introduction of the therapeutic agent teprotumumab, which dramatically reduces proptosis. However, concerns remain about the development of hearing impairment as a potentially fatal complication and long-term safety. Recently, several clinical trials are underway to assess the efficacy and safety of novel drugs targeting mammalian target of rapamycin complex 1, interleukin-6, fragment crystallizable receptor, and IGF-1R in treating TED. With the explosive increase in interest from academia and pharmaceutical companies in TED, there is anticipation for the development of drugs that are equivalent or superior to teprotumumab while being safer.

목차

Introduction

Conventional Treatments

Novel Treatments

Conclusion

References

키워드

Fragment crystallizable receptor Insulin-like growth factor 1 receptor Interleukin-6 Teprotumumab Thyroid eye disease