Pulsed low-dose rate radiotherapy for recurrent bone sarcomas: case reports and brief review

• 영문명: Pulsed low-dose rate radiotherapy for recurrent bone sarcomas: case reports and brief review
• 발행기관: 대한방사선종양학회
• 저자명: Ru Xin Wong Zubin Master Eric Pang Valerie Yang Wen Shen Looi
• 간행물 정보: 『대한방사선종양학회지』제42권 제1호, 88~94쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.03.30

영문 초록

Purpose: Re-irradiation for bulky recurrent sarcoma carries significant risks. Pulsed low-dose rate radiotherapy (PLDR) is an attractive option for re-irradiation due to inherent radiobiological advantages. Materials and Methods: We present two patients who underwent re-irradiation using PLDR technique, followed by a literature review. Results: The first case is that of a 76-year-old male who developed an in-field recurrence of a bulky pelvic bone high-grade chondrosarcoma after he was treated with definitive radiotherapy using helical TomoTherapy with a total dose of 66 Gy. The patient was re-irradiated using PLDR with a shrinking field technique; 50 Gy in 2 Gy fractions followed by a boost of 20 Gy in 2 Gy fractions. The patient remains disease-free without significant toxicity 60 months post-irradiation. The second case is that of an 82-year-old female who was treated with a definitive irradiation of 66 Gy in 33 fractions for a right shoulder grade II chondrosarcoma. She developed an in-field recurrence 28 months later and presented with bulky disease causing brachial plexopathy and lymphedema. The patient was re-irradiated with a palliative intent to a total dose of 50 Gy in 2 Gy fractions over 5 weeks using PLDR. Brachial plexopathy resolved shortly after re-irradiation, but local progression near the surface was evident 8 months later. She passed away from unrelated causes 11 months later. Conclusion: We present two cases highlighting our early experience with PLDR, which was effective in the re-irradiation of recurrent bony sarcoma. Our study highlights PLDR as an option for re-irradiation in recurrent unresectable tumors.

목차

Introduction

Case Report

Discussion

Statement of Ethics

Conflict of Interest

Acknowledgement

Funding

Author Contributions

Data Availability Statement

References

키워드

Sarcoma Radiotherapy Bone and bones Recurrence