Potential for Efficient Synthesis of GSH Utilizing GCS1 and GLR1 Mutant Strains of Candida albicans

• 영문명: Potential for Efficient Synthesis of GSH Utilizing GCS1 and GLR1 Mutant Strains of Candida albicans
• 발행기관: 한국식품보건융합학회
• 저자명: Jaeyoung SON Min-Kyu KWAK
• 간행물 정보: 『식품보건융합연구』제10권 2호, 7~11쪽, 전체 5쪽
• 주제분류: 복합학 > 과학기술학
• 파일형태: PDF
• 발행일자: 2024.03.30

영문 초록

Glutathione (GSH) is a vital compound composed of glutamic acid, cysteine, and glycine, crucial for cellular functions including oxidative stress defense and detoxification. It has widespread applications in pharmaceuticals, cosmetics, and food industries due to its antioxidant properties and immune system support. Two primary methods for GSH synthesis are enzymatic and microbial fermentation. Enzymatic synthesis is efficient but costly, while microbial fermentation, particularly using yeast strains like Candida albicans, offers a cost-effective alternative. This study focuses on genetically modifying C. albicans mutants, specifically targeting glutathione reductase (GLR1) and gamma-glutamylcysteine synthetase (GCS1) genes, integral to GSH synthesis. By optimizing these mutants, the research aims to develop a model for efficient GSH production, potentially expanding its applications in the food industry.

목차

1. Introduction

2. Materials and Methods

3. Results and Discussion

References

키워드

Glutathione (GSH) GSH synthesis Candida albicans