천연 생약에서 추출한 지표성분들의 모발 성장에 미치는 영향

• 영문명: Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 최부영
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』9권 2호, 58~67쪽, 전체 10쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Many people around the world are stressed by hair loss, and drug-based therapies (minoxidil, finasteride) are available for the treatment of alopecia, but they have several side effects. Therefore, in order to reduce the side effects of anti-hair loss drugs, the use of new treatments using products developed from natural extracts has been emphasized. In this study, we focused on the mechanisms underlying the hair growth-promoting effects of marker compounds of natural herbal extracts. The 32 marker compounds of natural herbal (10 μM) were used to evaluate the growth of human hair follicle dermal papilla cells, the expression of mRNA genes, and the signaling transcription factor activities of Wnt and JAKs. Seven marker compounds were selected that induced equal or greater growth than minoxidil or tofacitinib in cell growth. For the seven marker compounds, we evaluated the expression of mRNA genes and the transcriptional activities of Wnt/β-catenin and IL-4/JAK3-STAT6, which are major signaling pathways that regulate hair growth. As a result of the evaluation, it was scientifically proven that the 4 marker compounds (honokiol, isoalantolactone, broussochalcone A, and 3-deoxysappanone B) induce hair growth. I have suggested the possibility of developing a natural product for improving hair loss with 4 marker compounds.

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키워드

natural herbal marker compounds hair growth Wnt JAKs human hair follicle dermal papilla cells