Relative Risks for Dementia among Individuals with Glaucoma: A Meta-Analysis of Observational Cohort Studies

• 영문명: Relative Risks for Dementia among Individuals with Glaucoma: A Meta-Analysis of Observational Cohort Studies
• 발행기관: 대한안과학회
• 저자명: Min Gu Huh Young Kook Kim Jaekyoung Lee Young In Shin Yun Jeong Lee Sooyeon Choe Dai Woo Kim Yoon Jeong Jin Wook Jeoung Ki Ho Park
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.37 No.6, 490~500쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Purpose: To investigate the relative risks (RRs) for dementia among individuals with glaucoma. Methods: We conducted a search of PubMed, Web of Science, Scopus, and Cochrane databases for observational cohort studies examining the association between glaucoma and dementia until March 2023. Two authors independently screened all titles and abstracts according to predefined inclusion and exclusion criteria. Pooled RR and 95% confidence intervals (CIs) were generated using random-effect models. Results: The meta-analysis included 18 cohort studies conducted in eight countries and involving 4,975,325 individuals. The pooled RR for the association between glaucoma and all-cause dementia was 1.314 (95% CI, 1.099-1.572; I2 = 95%). The pooled RRs for the associations of open-angle glaucoma with Alzheimer dementia and Parkinson disease were 1.287 (95% CI, 1.007-1.646; I2 = 96%) and 1.233 (95% CI, 0.677-2.243; I2 = 73%), respectively. The pooled RRs for the associations of angle- closure glaucoma with all-cause dementia and Alzheimer dementia were 0.978 (95% CI, 0.750-1.277; I2 = 17%) and 0.838 (95% CI, 0.421-1.669; I2 = 16%), respectively. No evidence of publication bias was detected in the Begg-Mazumdar adjusted rank correlation test (p = 0.47). Conclusions: Based on current observational cohort studies, there is evidence supporting that glaucoma is a risk factor for dementia in the adult population.

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키워드

Alzheimer disease Dementia Glaucoma Meta-analysis Open-angle glaucoma