The Mechanisms of MuRF1 Ubiquitylation

• 영문명: The Mechanisms of MuRF1 Ubiquitylation
• 발행기관: 아시아운동학회
• 저자명: Peter W.J. Dawson Jimi Ng Yu-Chiang Lai
• 간행물 정보: 『Physical Activity 』Vol.1 No.1, 18~27쪽, 전체 10쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2023.11.17

국문 초록

MuRF1 (TRIM63) has been long known as a critical regulator in skeletal muscle atrophy. Over two decades of research has made evident that MuRF1’s expression is critical to the development of muscle atrophy. However, the development of atrophy inhibiting pharmaceuticals targeting MuRF1 has been hindered as MuRF1’s ubiquitin E3 ligase activity remains uncharacterised. The mechanism regulating MuRF1 activity, substrate recognition, and downstream effectors are unclear. This review aims to highlight the current research of molecular mechanisms by providing insights regarding MuRF1’s cooperating UBE2s, the topology of MuRF1 ubiquitylation, and the fates of MuRF1 substrates.

목차

Introduction

MURF1 AS A TRIM/RBCC UBIQUITIN E3 LIGASE

THE BIOCHEMICAL MECHANISM OF MURF1 UBIQUITYLATION

Conclusion and Remarks

Conflicts of Interest

Acknowledgements

References

키워드

Muscle Atrophy RING E3 Ligase (UBE3) Ubiquitin Conjugating Enzyme (UBE2)