외상 후 스트레스 장애 잔단 유무에 따른 고령의 재향 군인의 뇌백질 고신호 차이

• 영문명: Differences in White Matter Hyperintensity in Elderly Veterans With and Without Post-Traumatic Stress Disorder
• 발행기관: 대한노인정신의학회
• 저자명: 이은영 배희원 이승훈 최진희 최하연
• 간행물 정보: 『노인정신의학』제27권 제1호, 16~22쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.04.30

영문 초록

Objective: Exposure to stressful events is associated with the progression of white matter hyperintensity (WMH). The purpose of this study was to determine the difference in WMH depending on the presence of Post-traumatic stress disorder (PTSD). Methods: The patients who underwent brain magnetic resonance imaging and clinician-administered PTSD scale (CAPS) at the Veteran Health Service Medical Center were reviewed retrospectively. WMH were evaluated using the Fazekas scale. The patients with PTSD (n=51; age 66.25±10.43 years) were compared with patients exposed to trauma without PTSD (n=67; age 69.45±10.44 years). Results: The scores of Beck Depression Scale, Beck Anxiety scale, and CAPS were significantly higher in the PTSD group. The PTSD group showed a significant difference on the Fazekas scale compared to the trauma-exposed group without PTSD (periventricular white matter, p=0.001; deep white matter, p=0.008). After adjusting for age, smoking and comorbidity, WMH was higher in the PTSD group than in the trauma exposed group (periventricular white matter, p<0.001; deep white matter, p=0.006). Conclusion: The results suggests that there may be an association between PTSD and WMH as well as stressful events

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외상 후 스트레스 장애 뇌백질 고신호 재향 군인 Post-traumatic stress disorder White matter hyperintensity Veterans