랫드에서 Aldehyde Dehydrogenase Related Compounds의 알콜 및 알데히드 분해 효능평가

• 영문명: Anti-Alcohol and Anti-Aldehyde Hangover Effect of Aldehyde Dehydrogenase Related Compounds in Rat
• 발행기관: 한국환경보건학회
• 저자명: 신혜정(Hye-Jeong Sin) 정세영(Se-Young Choung) 강소라(Sora Kang) 권흥택(Hung-Taeck Kwon) 김배환(Bae-Hwan Kim)
• 간행물 정보: 『1. 한국환경보건학회지』제49권 제2호, 99~107쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2023.04.30

영문 초록

Background: Excessive alcohol consumption is at the root of serious social problems such as hangovers, liver dysfunction, and alcoholism. Objectives: This study was carried out to determine the hangover ameliorating effect of fermented rice extract and a combination of yeast-fermented powder and lysate containing aldehyde dehydrogenase (ALDH) (improved new ingredients) in an ethanol-induced rat study. Methods: The concentrations of alcohol, acetaldehyde, and malondialdehye in serum were evaluated to assess the anti-alcohol and anti-aldehyde hangover effect in two experiments, one with fermented rice extract) and a second with yeast-fermented powder and lysate, using animal studies. Results: Experiment 2 with yeast-fermented powder and lysate containing ALDH showed similar and higher activity, respectively, in reducing ethanol and acetaldehyde concentration compared with Experiment 1 with fermented rice extract. Experiment 2 also significantly reduced malondialdehyde, a type of lipid peroxide. The ALDH-related compound (ARC) lysate showed better hangover relief effect than ARC powder. Conclusions: These results indicate that ALDH-related compounds exhibit a hangover relief effect, and fermented lysate is considered to be a better candidate for hangover relief.

키워드

Anti-alcohol hangover ALDH-related compounds ADH malondialdehyde rat