Neurobehavioural effects of exposure of wistar rats to smoke from traditional Carica papaya (pawpaw) leaves

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Aboyeji Lukuman Oyewole Bamidele Victor Owoyele
• 간행물 정보: 『셀메드』Volume 2 Issue 4, 1~4쪽, 전체 4쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.11.30

영문 초록

This study was carried out to investigate the neurobehavioural effects of the smoking of Carica papaya leaves based on ethnopharmacological information. Twenty -four rats used for the study were grouped into four groups namely; Groups 1 (Control, unexposed to any smoke) and Groups 2 - 4 (exposed to smoke from varying amount of pawpaw leaf powder). Groups 2, 3, and 4 were exposed to smoke from 6.25 g (low dose), 12.50 g (medium dose), and 18.75 g (high dose) of dry pawpaw leaves respectively in a smoking chamber twice daily for 21 one days with each exposure lasting 3 min. The spontaneous motor activities and locomotory behaviour of the animals were assessed using an open field maze and hole board maze test. The results showed that the smoking of Carica papaya leaves led to a significant (p < 0.05) increase in locomotory activities from 33.36 ± 3.36 (control) to 66.50 ± 6.16 (high dose), number of head dips (from 8.50 ± 0.36, to 12.83 ± 0.87) and rearing behaviour (from 14.83 ± 0.74, to 27.0 ± 1.46). However, the freezing durations as animals were introduced into the maze and grooming behaviour were significantly (p < 0.05) reduced in the treated groups. In conclusion, the increased ambulations and exploratory behaviours imply that the anxiety level is low in the treated groups compared to the control group which thus confirms that dry Carica papaya leaf may possibly contain psychoactive substance(s) that become active when smoked.

키워드

Anxiety Carica papaya hole board test maze test neurobehaviour rats smoke