Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Li Du Man-man Li Bai-Xia Zhang Shuai-Bing He Ya-Nan Hu Yun Wang
• 간행물 정보: 『셀메드』Volume 5 Issue 4, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2015.11.30

영문 초록

Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.

키워드

Prunella Vulgaris hypertension mechanism entity grammar systems