The regulatory effect of AST cream on atopic dermatitis-like skin disease

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Na-Ra Han Hyung-Min Kim Hyun-Ja Jeong
• 간행물 정보: 『셀메드』Volume 9 Issue 3, 1~4쪽, 전체 4쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2019.08.31

영문 초록

In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4- dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.

키워드

AST cream histamine IgE atopic dermatitis