학술논문
Quality Control of Majoon-e-Nisyan and its Acute Oral Toxicity Study in Experimental Rats
이용수 3
- 영문명
- 발행기관
- 셀메드 세포교정의약학회
- 저자명
- Masud Shaikh Gulam M. Husain Mohammed Abdul Rasheed Naikodi Munawwar H. Kazmi Uzma Viquar
- 간행물 정보
- 『셀메드』Volume 11 Issue 1, 1~8쪽, 전체 8쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2021.02.26
무료
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국문 초록
영문 초록
The clinical condition Amnesia causes difficulty in learning new information and the inability to recall past events. It is primarily concerned with recent memory loss.
Majoon-e-Nisyan (MJN) is a polyherbal Unani formulation, present in a semi-solid form. It is widely used potent drug of the Unani System of Medicine (USM) for treating Nisyan (amnesia). In the present study polyherbal Unani formulation, MJN has been studied for its quality control and acute toxicity. Standardization (quality control) of drugs deals with drug identity, drug quality and purity determination. Standardization of MJN had been done as per the Unani pharmacopoeial parameters approved by World Health Organization (WHO) - Pharmacognostical parameters, Physico-chemical parameters, high-performance thin-layer chromatography (HPTLC), microbial load, aflatoxin, and heavy metals. Solvents and chemicals used in the study were of analytical grade and used instrument were calibrated. By conducting an acute oral toxicity study in rats, the safety of MJN was assessed. The limit test method of OECD guideline 425 was followed in the study. Results of standardization and standard operating procedures (SOPs) for preparation of MJN may serve as the standard reference in the future. The data generated in the study for the quality control of MJN proved the quality of formulation and shows that MJN is not toxic in rats following acute dosing up to 2000 mg/kg bw. The data obtained in the paper for MJN may be used as a standard guideline for preparation of the formulation which can save time, cost, and resources for future research endeavours.
목차
해당간행물 수록 논문
- An In sight into Novel Drug Delivery System: In Situ Gels
- Standardization and HPTLC Fingerprinting of a Polyherbal Unani Formulation
- Quality Control of Majoon-e-Nisyan and its Acute Oral Toxicity Study in Experimental Rats
- Virechana karma (therapeutic purgation) in the restoration of gut microbiota concerning Amavata (RA): A scientific exposition
- The power of BanLyeo (伴侶, companion) music: better than medicine (https://youtu.be/GTfOIJ7bZbo)
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