APOE ε4 보인자의 지방 관련 체성분 수치 증가에 따른 휴지기 신경망 간 기능적 연결성 감소

• 영문명: Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition
• 발행기관: 대한노인정신의학회
• 저자명: 최인혁 왕성민 엄유현 임현국 이창욱 강동우
• 간행물 정보: 『노인정신의학』제26권 제2호, 76~83쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.10.31

영문 초록

Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition. Methods: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F] flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network (SN). Results: There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC. Conclusion: The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.

목차

서 론

대상 및 방법

결 과

고 찰

REFERENCES

키워드

체성분 APOE ε4 보인자 생체 전기저항 측정법 기능적 연결성 경도인지장애 Body composition APOE ε4-carrier Bioelectrical impedance analysis Functional connectivity Mild cognitive impairment