레이저 투과 선량에 따른 황색포도상구균의 광역학적 비활성화

• 영문명: Photodynamic Inactivation of Staphylococcus Aureus Based on Dose of Laser Transmission
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 저자명: 구본열(Bon-Yeoul Koo) 김지원(Ji-Won Kim)
• 간행물 정보: 『방사선기술과학』방사선기술과학 제45권 제2호, 165~170쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Staphylococcus aureus is a major pathogen that causes clinical infections in humans and can also cause massively colonized in lesion skin, particularly in atopic dermatitis patients. This study investigated the effects of photodynamic inactivation with radachlorin and diode laser irradiation on the viability of S. aureus in vitro and assessed the effects of the dose of laser transmission. In the PDI group, 5 μL of S. aureus suspension and 5 μL of radachlorin were inoculated in a 55 mm petri dish (63.6 cm2). The samples were placed in a 37° incubator for 30 min and then irradiated with light (660 nm diode laser). After laser irradiation, the cells were stored for 24 h at 37° in an incubator with 5% CO2, and the number of colonies was counted. All CFU/mL of S. aureus were reduced by diode laser in the presence of radachlorin, with a killing rate of 87.9% at an energy dose of 9 J/cm2. This study contribute to treat colonized with S. aureus in atopic dermatitis patients and wound infections by providing information on the optimal dose of laser transmission using PDI to eliminate S. aureus.

목차

Ⅰ. 서 론

Ⅱ. 실험 재료 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

REFERENCES

키워드

광역학 요법 황색포도상구균 레이저 선량 광과민제 라다클로린 Photodynamic inactivation Staphylococcus aureus Laser dose Photosensitizer Radaclorin