폐금속광산 지역 주민의 비소 대사에 영향을 미치는 MTHFR , As3MT, GSTO1 유전자 다형성

• 영문명: MTHFR, As3MT and GSTO1 Polymorphisms Influencing Arsenic Metabolism in Residents Near Abandoned Metal Mines in South Korea
• 발행기관: 한국환경보건학회
• 저자명: 울지(Ulziikhishig Surenbaatar) 김병권(Byoung-Gwon Kim) 손현진(Hyun-Jin Son) 조성식(Seong-Sik Cho) 김권민(Gwon-Min Kim) 임현주(Hyoun-Ju Lim) 권정연(Jung-Yeon Kwon) 김기환(Ki-Hwan Kim) 홍영습(Young-Seoub Hong)
• 간행물 정보: 『1. 한국환경보건학회지』제47권 제6호, 530~539쪽, 전체 10쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2021.12.31

영문 초록

Background: In South Korea, areas around abandoned metal mines are designated as regions with high arsenic (As) contamination. However, studies assessing urinary As exposure, As metabolism, and relevant genetic polymorphisms in residents of these metal mine areas are lacking. Objectives: To identify factors associated with As exposure and evaluate the effects of MTHFR , As3MT, and GSTO1 genetic polymorphisms on As metabolism in residents of abandoned metal mine areas by measuring urinary As species. Methods: Urinary As species (arsenite [As3+], arsenate [As5+], monomethyl arsonic acid, and dimethylarsinic acid) were isolated using high-performance liquid chromatography in combination with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Four genetic polymorphisms (MTHFR A222V, MTHFR E429A, GSTO1 A140D, As3MT M287T) were analyzed in 144 residents of four areas around abandoned metal mines. Results: The study sample was comprised of 34.7% men and 65.3% women, with a mean age of 70.7±10.9 years. The urinary inorganic As concentration was higher among those consuming more than half locally produced rice (0.31 μg/L) than those consuming less than half such rice (0.18 μg/L). The urinary dimethylarsinic acid concentration was higher in the group that had consumed seafood in the past day (31.68 μg/L) than in those who had not (22.37 μg/L). Furthermore, individuals heterozygous in the MTHFR A222V and GSTO1 A140D polymorphism had higher urinary arsenic species concentrations than did individuals with a wild type or homozygous for the variant allele. Conclusions: Consumption of locally produced rice was associated with inorganic As exposure, whereas seafood consumption was associated with organic As exposure among residents of abandoned metal mine areas. There was no clear association between MTHFR A222V and GSTO1 A140D polymorphisms and As metabolism.

목차

Ⅰ. 서 론

Ⅱ. 재료 및 연구방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

감사의 글

Conflict of Interest

References

키워드

Urinary arsenic speciation genetic polymorphisms MTHFR As3MT GST01 abandoned metal mine