노화성 근감소증과 운동

• 발행기관: 대한운동학회
• 저자명: 허준원(Jun-Won Heo) 노미현(Mi-Hyun No) 박동호(Dong-Ho Park) 강주희(Ju-Hee Kang) 곽효범(Hyo-Bum Kwak)
• 간행물 정보: 『아시아 운동학 학술지』제19권 제2호, 43~59쪽, 전체 17쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2017.04.30

영문 초록

Aging-induced Sarcopenia and Exercise. Kinesiology, 2017, 19(2): 43-59. [PURPOSE] Aging is associated with a progressive loss of skeletal muscle mass and strength as well as physical performance called sarcopenia. Sarcopenia is one of the leading causes of disability in the elderly. Despite the growing prevalence of sarcopenia, the cellular and molecular mechanisms of the aging-related sarcopenia are not fully understood. The purpose of this paper was to review the potential mechanisms of aging-induced sarcopenia and the effects of aerobic and resistance exercise on sarcopenia. [METHODS] A literature review was conducted via web based search engines such as the PUBMED and OVID to collect data and information. [RESULTS] Mitochondria in skeletal muscle may be consid-ered a major factor underlying aging-induced sarcopenia. Alterations in mitochondrial function increase oxidative stress (ROS), interfere with mitochondrial dynamics leading to the unbalance between fusion and fission, impair mitochondrial autophagy (mitophagy), and trigger mitochondrial-mediated apoptosis in aging skeletal muscle. In addition, increased pro-inflammatory cytokines and decreased sex hormones may be associated with aging-induced sarcopenia. [CONCLUSIONS] In this review, we summarize the current knowledge on the potential mechanisms of the aging-related sarcopenia, and highlight the effects of aerobic exercise and resistance exercise on sarcopenia in aging skeletal muscles, suggesting that combined exercise may be the most effective to protect against aging-induced sarcopenia.

목차

서론

노화성 근감소증의 잠재적 기전들

노화성 근감소증에 대한 운동의 효과

결론

참고문헌

키워드

노화 골격근 근감소증 유산소운동 저항성운동 aging skeletal muscle sarcopenia aerobic exercise resistance exercise