학술논문
Studies on Anti-Cancerous Substances from Higher Plants in East Asian Region
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- 영문명
- 발행기관
- 한국자원식물학회
- 저자명
- Koichi Takeya
- 간행물 정보
- 『Plant Resources』Vol.3 No.1, 1~45쪽, 전체 45쪽
- 주제분류
- 농수해양 > 기타농수해양
- 파일형태
- 발행일자
- 2000.05.31
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국문 초록
영문 초록
To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for cancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids. lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically. Oridonin isolated from Rabdosia ssp. is now investigate for clinical trials in China. Moreover camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifolia. has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential Some efforts are continued in National Cancer Institute(NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin 111, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected In Japan, China, Korea. Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia In mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma(KB) cells in our laboratory, as primary screening. In this meeting, I will present on antitumor and cytotoxic substances of the higher plants(Rubis cordifolia, Ailanthus vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var. drupacea, etc.) selected from above screening tests.
목차
INTRODUCTION
TERPENES
ALKALOIDS
PHENOLS
CYCLIC OLIGOPEPTIDES
해당간행물 수록 논문
- Studies on Anti-Cancerous Substances from Higher Plants in East Asian Region
- Temperature Effect on Seed Germination and Seedling Growth of Medicinal Umbelliferae Plants
- Ethnopharmacology, bioactivities and chemical constituents of some anti-cancer plants in Malaysia
- The present situation of studies on effects of atitumor with health of Hippophae in the China
- Effects of Chemical Compounds on Vase Life and Microbial Growth of Cut Calla Flowers
- Anti-Cancer Mushroom of Toadstool in Korea
- Resources of woody plant in Taejon Area, Korea
- Evaluation of Alfalfa Autotoxicity on Germination and Early Seedling Growth of 3 Cultivars
- The principles of posionous mushrooms, their unexpected utilitie
- Natural Plant-Red Sage Root and Anti-cancer
참고문헌
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