학술논문
A rice bran phytochemical, cyanidin 3-glucoside, inhibits the progression of PC3 prostate cancer cell
이용수 5
- 영문명
- 발행기관
- 대한해부학회
- 저자명
- Kamonwan Jongsomchai Vijittra Leardkamolkarn Sugunya Mahatheeranont
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.53(4), 481~492쪽, 전체 12쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2020.12.30
4,240원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Prostate cancer is one of the high incidences and the most invasive cancer that is also highly resistant to chemotherapy. Currently, several natural products have been considering using as the supplements for anti-cancer therapy. This study aims to identify the potential active anti-cancer ingredients in the bran extracts of the native Thai rice (Luempua cultivar). Rice bran fraction enriched in anthocyanins was successively isolated and processed until the major purified compound obtained. The sub-fractions and the purified, rice bran, cyanidin 3-glucoside (RBC3G), were studied for biological effects (cell viability, migration, and invasion assays) on human prostatic cancer (PC3) cells using immunohistochemical-staining and immuno-blotting approaches. The sub-fractions and the purified RBC3G inhibited epithelial mesenchymal transition (EMT) characteristics of PC3 cells by blocking the expression of several cytoskeletal associate proteins in a concentration dependent manner, leading to decreasing of the cancer cell motility. RBC3G reduced the expression of Smad/Snail signaling molecules but enhanced the expression of cell surface protein, E-cadherin, leading to a delay tumor transformation. The RBC3G also inhibited matrix metalloproteinase-9 and nuclear factor-kappa B expression levels and the enzymes activity in PC3 cells, leading to a slow cell migration/invasion process. The results suggested that RBC3G blunt and/ or delay the progressive cancer cell behaviors by inhibit EMT through Smad signaling pathway(s) mediating Snail/E-cadherin expression.
목차
Introduction
Materials and Methods
Results
Discussion
ORCID
Author Contributions
Conflicts of Interest
Acknowledgements
References
해당간행물 수록 논문
- Cervical nerve roots and the dural sheath: a histological study using human fetuses near term
- A rice bran phytochemical, cyanidin 3-glucoside, inhibits the progression of PC3 prostate cancer cell
- An unusual anatomical variation of the inferior alveolar nerve
- Intraluminal anatomy of the transverse sinus: implications for endovascular therapy
- Nicotinamide adenine dinucleotide phosphate oxidase inhibitor induces apoptosis on Epstein-Barr virus positive B lymphoma cells
- Duplication of the odontoid process with other congenital defects of the craniocervical Junction: case report and review of the literature
- Effect of cypermethrin on the postnatal development of the medulla oblongata and the possible protective role of melatonin in albino rats
- Acromial morphology and morphometry associated with subacromial impingement syndrome
- Camillo Golgi (1843-1926): scientist extraordinaire and pioneer figure of modern neurology
- An unusual finding of the pectoralis major muscle: decussation of sternal fibers across the midline
- Fetal development of the human trapezius and sternocleidomastoid muscles
- Sternalis muscle in jordanian population: a prevalence study and level of physicians’ awareness
- Comparative evaluation of the ultrastructural morphology and distribution of filiform and fungiform tongue papillae in Egyptian mice, fruit bats and long-eared hedgehogs
- Direct drainage of the basal vein of Rosenthal into the superior petrosal sinus: a literature review
- Case report of a vertical straight sinus with hydrocephalus and Chiari I malformation
- Retromandibular vein position and course patterns in relation to mandible: anatomical morphologies requiring particular vigilance during sagittal split ramus osteotomy
- Anatomical study and branching point of neurovascular structures at the medial side of the ankle
- New insights in anterior cruciate ligament morphology: implications for anterior cruciate ligament reconstruction surgeries
- The terminal ventricle of Saguinus leucopus (Primate)
- A rare case of trifid mandibular canal with bilateral retromolar foramina
- Caudal regression syndrome and a pelvic kidney: case report
- Anatomical variations of the stylopharyngeus and superior constrictors in relation to their function
참고문헌
관련논문
의약학 > 의학일반분야 BEST
- 교육전담간호사가 주도하는 임상현장교육 프로그램이 신규 간호사의 간호업무성과와 교육 만족도에 미치는 효과
- 일반인을 위한 해부학 만화
- 간호대학생의 MBTI 성격유형별 의사소통능력, 자아존중감, 학업성취도의 관계
의약학 > 의학일반분야 NEW
- Pectolinarigenin ameliorated airway inflammation and airway remodeling to exhibit antitussive effect
- Ferroptosis and its role in gastric and colorectal cancers
- Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!