학술논문
TA 약침의 안전성 평가
이용수 24
- 영문명
- Safety Study of TA Pharmacopuncture: Bacterial Reverse Mutation Test
- 발행기관
- 임상약침학회
- 저자명
- 정철(Chul Jung) 황지혜(Ji Hye Hwang)
- 간행물 정보
- 『임상약침학회학회지』대한면역약침학회지 제6권 제1호, 1~11쪽, 전체 11쪽
- 주제분류
- 의약학 > 한의학
- 파일형태
- 발행일자
- 2017.12.30
4,120원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Objectives : To evaluate the safety of TA pharmacopuncture, bacterial reverse mutation test was performed using histidine requiring Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and tryptophan requiring Escherichiacoli (WP2uvrA (pKM101)) strains in the absence and presence of metabolic activation.
Methods : TA pharmacopuncture was prepared by extracting from a herbal mixture (Scutellariae Radix 20 g, Phellodendri Cortex 20 g, Pulsatillae Radix 20 g, Sophorae Tonkinensis Radix et Rhizoma 20 g, Aucklandiae Radix 10 g, Carthami Fructus 30 g) using a mixture solvent of purified water for injection (500 mL) and alcohol (500 mL). In order to determine the dose levels of the main study, the dose range finding study was performed. The high dose of TA pharmacopuncture was selected at 100% and it was sequentially diluted by applying a geometric ratio of 2 to produce lower dose levels of 50.0, 25.0, 12.5, and 6.25%. The treatment volume was 100 μL. As a result, the growth inhibition and precipitation of the test substance were not evident at any dose level in each strain in the absence and presence of metabolic activation. Therefore, the dose levels of the main study were selected as 100, 50.0, 25.0, 12.5, and 6.25%. Also, the negative and positive control groups were set.
Results : The mean number of revertant colonies was less than twice when compared to the negative control values at all dose levels of the TA pharmacopuncture in the presence and absence of metabolic activation, showing no dose-related increase. In the positive control group, the number of revertant colonies was markedly increased by more than twice when compared to the negative control group.
Conclusions : TA pharmacopuncture did not exhibit any indications of mutagenic potential under the conditions of this study.
목차
Ⅰ. 서 론
Ⅱ. 재료 및 방법
Ⅲ. 결 과
Ⅳ. 고찰 및 결론
참고문헌
해당간행물 수록 논문
참고문헌
관련논문
의약학 > 한의학분야 NEW
- 신경성 식욕부진증의 치료에 관한 임상연구 동향
- 턱관절균형요법을 이용한 과개교합 치료가 성장에 미치는 영향 치험례
- 위로 치켜뜨는 운동 틱 장애 환자에 대해 턱관절균형요법을 병행한 한방치료 치험 1례
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!