제약단지 인접 지역 지표수의 잔류 의약물질 생태위해성평가

• 영문명: Ecological Risk Assessment of Pharmaceuticals in the Surface Water Near a Pharmaceutical Manufacturing Complex in Korea
• 발행기관: 한국환경보건학회
• 저자명: 박수현(Suhyun Park) 강하병(Habyeong Kang) 신혜수(Hyesoo Shin) 유일한(Ilhan Ryoo) 최경호(Kyungho Choi) 고영림(Younglim Kho) 박경화(Kyunghwa Park) 김경태(Kyungtae Kim) 지경희(Kyunghee Ji)
• 간행물 정보: 『1. 한국환경보건학회지』제46권 제1호, 45~64쪽, 전체 20쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2020.02.28

영문 초록

Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near a pharmaceutical manufacturing complex. Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a harmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC. Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored. Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.

목차

I. 서 론

II. 연구 방법

III. 연구 결과 및 고찰

IV. 결 론

키워드

Environmental risk assessment manufacturing site occurrence pharmaceutical water environment