Benefits of hesperidin in central nervous system disorders: a review

• 발행기관: 대한해부학회
• 저자명: Jeongtae Kim Myung-Bok Wie Meejung Ahn Akane Tanaka Hiroshi Matsuda Taekyun Shin
• 간행물 정보: 『Anatomy and Cell Biology』Vol.52(4), 369~377쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2019.12.30

영문 초록

Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals. Hesperidin, which is an abundant flavanone glycoside in the peel of citrus fruits, possesses a variety of biological capabilities that include antioxidant and anti-inflammatory actions. Over the last few decades, many studies have been investigated the biological actions of hesperidin and its aglycone, hesperetin, as well as their underlying mechanisms. Due to the antioxidant effects of hesperidin and its derivatives, the cardioprotective and anti-cancer effects of these compounds have been widely reviewed. Although the biological activities of hesperidin in neurodegenerative diseases have been evaluated, its potential involvement in a variety of central nervous system (CNS) disorders, including autoimmune demyelinating disease, requires further investigation in terms of the underlying mechanisms. Thus, the present review will focus on the potential role of hesperidin in diverse models of CNS neuroinflammation, including experimental autoimmune encephalomyelitis, with special consideration given to its antioxidant and anti-inflammatory effects in neurodegenerative disease models. Additionally, current evidence provides information regarding the nutraceutical use of hesperidin to prevent various CNS disorders.

목차

Introduction

Molecular Mechanisms of Hesperidin(Antioxidation and Anti-inflammation)

Bioactivity of Hesperidin in the Nervous System

Conclusion

ORCID

Author Contributions

Conflicts of Interest

Acknowledgements

References

키워드

Hesperidin Neuroinflammation Antioxidant Demyelination Hippocampus