학술논문
Efficacy and Safety of Intracameral Bevacizumab for Treatment of Neovascular Glaucoma
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- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Jun Young Ha Tae Hee Lee Mi Sun Sung Sang Woo Park
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.31 No.6, 538~547쪽, 전체 10쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2017.12.30
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국문 초록
영문 초록
Purpose: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular
glaucoma.
Methods: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral
bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP). The main outcome measures were changes in visual acuity, IOP, and neovascularization of the iris (NVI) and the anterior chamber angle (NVA).
To assess the safety of intracameral bevacizumab, corneal endothelial changes were also determined using
specular microscopy. Patients whose IOP was uncontrolled received IOP-lowering surgery. Clinical factors associated with IOP-lowering surgery were also investigated.
Results: In all patients, intracameral bevacizumab resulted in a rapid and marked reduction of IOP, NVI, and NVA within 1 week. At 12 months after initial injection, 19 of 26 eyes (73%) underwent IOP-lowering surgery.
The average interval between initial injection and surgical treatment was 33.6 ± 26.9 days. Baseline IOP(p = 0.018), NVA grade (p = 0.029), and incomplete PRP (p = 0.005) were identified as predictive factors for IOP-lowering surgery. During the follow-up period, there were no statistically significant corneal endothelial changes after intracameral bevacizumab injection.
Conclusions: During 1 year of follow-up after intracameral bevacizumab, the procedure was found to be safe for the corneal endothelium. However, the IOP-lowering effect was transient, and 73% of patients eventually required IOP-lowering surgery. Predictive factors for IOP-lowering surgery were high baseline IOP and NVA grade, and incomplete PRP.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
References
해당간행물 수록 논문
- Efficacy and Safety of Intracameral Bevacizumab for Treatment of Neovascular Glaucoma
- Comparison of Contact Lens Corrected Quality of Vision and Life of Keratoconus and Myopic Patients
- Blindness in Sweet’s Syndrome
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- Epiretinal Membrane: Prevalence and Risk Factors from the Korea National Health and Nutrition Examination Survey, 2008 through 2012
- Changes in Macular Retinal Layers and Peripapillary Nerve Fiber Layer Thickness after 577-nm Pattern Scanning Laser in Patients with Diabetic Retinopathy
- Scleral Buckling Using a Non-contact Wide-Angle Viewing System with a 25-Gauge Chandelier Endoilluminator
- Correlation between Uncorrected Visual Acuity and Macular Distortion in Idiopathic Epiretinal Membrane Patients
- Retinopathy of Prematurity-assist: Novel Software for Detecting Plus Disease
- Efficacy and Safety of a Large Conjunctival Autograft for Recurrent Pterygium
- Management of Anterior Chamber Migration of Dexamethasone Intravitreal Implant
- Analysis of the Retinal Nerve Fiber Layer Thickness in Alzheimer Disease and Mild Cognitive Impairment
- Patient Awareness of Cataract and Age-related Macular Degeneration among the Korean Elderly: A Population-based Study
- Intraocular Lens Power Calculation after Refractive Surgery: A Comparative Analysis of Accuracy and Predictability
- Spontaneous Resolution of Macular Hole with Retinal Detachment in a Highly Myopic Eye
참고문헌
관련논문
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