학술논문
Effective Delivery of Exogenous Compounds to the Optic Nerve by Intravitreal Injection of Liposome
이용수 7
- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Junsung Lee Unbyeol Goh Ji-Ho Park Sang-Woo Park Hwan Heo
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.32 No.5, 417~423쪽, 전체 7쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2018.10.30
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국문 초록
영문 초록
Purpose: To improve the treatment efficiency of optic nerve diseases by delivering therapeutic materials to the optic nerve directly.
Methods: We tried to optimize liposomal composition to deliver a payload to the optic nerve efficiently when it is
injected intravitreally. After loading dexamethasone into this liposome, we tested the therapeutic effect of liposomes
in this treatment using a murine model of ischemic optic neuropathy.
Results: Our optimized liposome can deliver its payload to the optic nerve more efficiently than other tested compositions. Moreover, dexamethasone-loaded liposomes had a significant therapeutic effect in a murine
model of ischemic optic neuropathy.
Conclusions: Here, we demonstrate the optimal composition of liposomes that could efficiently deliver intravitreally
injected exogenous compounds to the optic nerve. We expect that the intravitreal injection of liposomes
with the suggested composition would improve the delivery efficacy of therapeutic compounds to the optic nerve.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
Acknowledgements
References
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