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• 영문명: Comparison of Human Blood Cadmium Concentrations using Graphite Furnace Atomic Absorption Spectrometry (GF-AAS) and Inductively Coupled Plasma-mass Spectrometry (ICP-MS)
• 발행기관: 한국환경보건학회
• 저자명: 권정연(Jung-Yeon Kwon) 김병권(Byoung-Gwon Kim) 임현주(Hyoun-Ju Lim) 서정욱(Jeong-Wook Seo) 강민경(Min-Kyung Kang) 김유미(Yu-Mi Kim) 홍영습(Young-Seoub Hong)
• 간행물 정보: 『1. 한국환경보건학회지』제44권 제5호, 491~501쪽, 전체 11쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

Objectives: The aims of this study were to compare concentrations and the correspondence of human blood cadmium by using graphite furnace atomic absorption spectrometry (GF-AAS) and inductively coupled plasmamass spectrometry (ICP-MS), which are representative methods of heavy metal analysis. Methods: We randomly selected 79 people who agreed to participate in the research project. After confirming the linearity of the calibration curves for GF-AAS and ICP-MS, the concentrations of cadmium in a quality control standard material and blood samples were measured, and the correlation and the degree of agreement were compared. Results: The detection limit of ICP-MS (IDL: 0.000 µg/L, MDL: 0.06 µg/L) was lower than that of GF-AAS (IDL: 0.085 µg/L, MDL: 0.327 µg/L). The coefficient of variation of the quality control standard material showed stable values f or both ICP-MS (clinchek-1: 5.35%, clinchek-2: 6.22%) and GF-AAS (clinchek-1 7.92%, clinchek-2: 5.22%). Recovery was relatively high for both ICP-MS (clinchek-1: 95.1%, clinchek-2: 92.8%) and GF-AAS (clinchek-1: 91.4%, clinchek-2: 98.8%), with more than 90%. The geometric mean, median, and percentile of blood samples were all similar. The agreement of the two instruments compared with the bias of the analytical values found that about 81% of the analytical values w ere within ± 30% of the deviation from the ideal reference line (y=0). As a result of the agreement limit, the value included in the confidence interval was about 94%, which shows high agreement. Conclusion: In this study, we confirmed there was no significant difference in concentrations of a quality control standard material and blood samples. Since ICP-MS showed lower concentrations than GF-AAS at concentrations below the method detection limit of GF-AAS, it is expected that more precise results will be obtained by analyzing blood cadmium with ICP-MS.

목차

I. 서 론

II. 대상 및 방법

III. 결 과

IV. 고 찰

V. 결 론

키워드

Cadmium ICP-MS GF-AAS degree of agreement