벤조피렌의 급성독성 수준에 따른 관리적 방안 연구

• 영문명: A Study on the Management of benzo[a]pyrene according to the Level of Acute Toxicity
• 발행기관: 한국환경보건학회
• 저자명: 김미나(Mina Kim) 이승길(Seungkil Lee) 이용식(Yongsik Lee) 조삼래(Samrae Cho) 김덕현(Dukhyun Kim)
• 간행물 정보: 『1. 한국환경보건학회지』제44권 제2호, 153~159쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2018.04.30

영문 초록

Objectives: This study was carried out to determine LD50 of benzo[a]pyrene to decide the possibility to designate them as toxic substance on the Act on the Registration and Evaluation, etc. of Chemical Substances, and to suggest that they should be managed in what level on the Chemical Control Act. Methods: Based on the result of a preliminary study, 300 mg/kg was set as the middle dose. A highest dose of 2,000 mg/kg and a lowest dose of 50 mg/kg were selected based on the OECD TG 423. Benzo[a]pyrene was orally administered once to female and male SD rats at dose levels of 50, 300, 2,000 mg/kg (body weight). All animals were monitored daily for clinical signs and mortality over 14 days. Also testicular spermatid count, motility and etc. were examined as well. Results: Under the condition of this experiment, LD50 of benzo[a]pyrene was assumed to be >2,000 mg/kg. In the lesion according to autopsy, there were no specific symptoms in the control and experimental groups. At 2,000 mg/kg, a decrease in the sperm motility was observed. Benzo[a]pyrene should be designated to be toxic substance as the material assumed to be reproduction-toxicity on the Act on the Registration and Evaluation, etc. of Chemicals. Therefore we should abide by legal procedures determined by Chemicals Control Act in treating it. Conclusion: Considering the significant result that sperm motility in the experimental group was inferior to that in the reference group, we suggest that benzo[a]pyrene be designated as a toxic substance.

목차

Ⅰ. 서 론

Ⅱ. 연구대상 및 방법

Ⅲ. 연구결과

Ⅳ. 고찰 및 결론

키워드

Benzo[a]pyrene acute toxicity act on the registration and evaluation etc of chemicals chemicals control act