Bilateral Papillary Thyroid Cancer Increases the Risk of Lymph Node Metastasis Compared with Unilateral Multifocal Papillary Thyroid Cancer

• 발행기관: 대한내분비외과학회
• 저자명: Ja Ryung Han 1 Jin Hyang Jung Wan Wook Kim Jeeyeon Lee Ho Yong Park Hye Jung Kim Ji-Young Park
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』17권2호, 63~72쪽, 전체 10쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2017.06.30

영문 초록

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated. Methods: Patients with PTC (n=819) undergoing thyroidectomy at our institution were included. The study population was segregated into 4 groups based on PTC multifocality and bilaterality. Results: Cervical lymph node metastasis, tumor size, and tumor extent were significantly different between the study groups. The frequency of central and lateral cervical lymph node metastasis was the highest in the bilateral multifocal disease group, followed by the bilateral solitary group, unilateral multifocal group, and the unilateral solitary group. One PTC focus per thyroid lobe was associated with increased metastasis (53.8%). Moreover, lymph node positivity doubled with 5–7 foci (71.4%), and tripled with ≥8 foci (100.0%). Bilateral solitary and bilateral multifocal PTC were identified as independent predictors of cervical lymph node metastasis. Conclusion: Bilateral PTC was associated with lymph node positivity, which increased proportionally with the number of PTC foci. Bilateral solitary or multifocal PTC were associated with more aggressive features such as larger primary tumor size, more frequent extrathyroidal extensions, and regional lymph node metastasis. The presence of multiple bilateral foci or more than 3 foci are independent risk factors of lymph node metastases.

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INTRODUCTION

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키워드

Papillary thyroid cancer Multifocal Bilateral Lymph node metastasis