In vitro에서 키토산 연고의 비타민 B₂ 방출 특성

• 영문명: Release Characteristics to Vitamin B₂ of Chitosan Ointments In vitro
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 오세영(Se Young Oh) 황성규(Sung Kwy Hwang) 황용현(Yong Hyun Hwang)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제17권 제1호, 43~48쪽, 전체 6쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2000.03.30

영문 초록

Drug delivery system(DDS) applied to various fields, such as medicine, cosmetics, agriculture and necessities of life. Among these application fields, DDS is often used as the method of drug dosage into the epidermic skin. We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying DDS. Chitosan was selected as material of TTS. We investigated the permeation of chitosan ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as riboflavin in vitro. We used glycerin. PEG 600 and oleic acid as enhancers. Since dermis has more content water(hydration) than the stratum comeum, skin permeation rate at steady state was highly influenced when glycerin was used in water-soluble drug. The permeation rate of content enhancer and drug was found to be faster than that of content water-soluble drug only. these results showed that skin permeation rate of drug across the composite was manly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.

목차

Abstract

Ⅰ. 서론

Ⅱ. 실험

Ⅲ. 결과 및 고찰

Ⅳ. 결론

참고문헌