Isothiazoline 유도체의 합성 및 정제에 관한 연구

• 영문명: A Study on the Synthesis and Refining of Isothiazoline Derivatives
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 성기천 김기준
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제14권 제2호, 93~102쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

Isothiazoline derivatives is widely used to food, medical drug and industrial goods, cosmetics etcs, and it makes to restrain and to sterilize a breeding of microbe as a preservative and a sterilizing agent. It differs with the raw material of paraoxybenzoic acid derivatives or imidazolydinyl urea to be in use at present, on the efficacy and effect, and has various characteristics. This synthesis makes 3,3 -dithiodipropionic chloride to add a thionyl chloride in 3,3 -dithiodipropionic acid, and 3,3 -dithiodipropionic methyl amide makes to synthesize in a reflux reaction the mono methyl amine to 3,3 -dithiodipropionic chloride. And last synthesis becomes to make chlorination-cyclization molecule doing a reflux reaction in the temperature of $90{\sim}100^{\circ}C$ 수식 이미지 to mix excessively thionyl chloride and ethylene dichloride to 3,3 -dithiodipropionic methyl amide. The last synthesis material has got in the mixture of 5-chloro-2-methyl-4-isothiazoline-3-one and 2-methyl-4-isothiazoline-3-one, and it is so-called isothiazoline derivatives. The purification of isothiazoline derivatives makes to fuse in ethyl acetate, and makes to decolorize and to deodorize in recrystallization. This experiment has been in synthesis and purification of isothiazoline derivatives, and has tried to measure on the antisepsis and sterilization function of microbe according to pH or content change.